4x Faster Symptom Relief (2024)

*Based on number of members
†vs all first-line prescription drug products
‡Based on a clinical study with MONISTAT® Combination Pack Ovule® treatment vs the leading prescription product
§2015 CDC Guidelines recommend the use of 7-day topical azole therapies for treatment of vulvovagin*l candidiasis (VVC) in pregnant women.
¶Per 2015 CDC Guidelines, options for first-line therapy of non-albicans VVC include longer duration therapy (7-14 days) with a non-fluconazole azole regimen.

REFERENCES: 1. van Heusden AM, Merkus HM, Corbeij HS, et al. Single-dose oral fluconazole versus single-dose topical miconazole for the treatment of acute vulvovagin*l candidosis. Acta Obstet Gynecol Scand. 1990;69(5):417-422. 2. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2015. http://www.cdc.gov/std/tg2015/tg-2015-print.pdf. Published June 5, 2015. Accessed August 14, 2015. 3. Marchaim D, Lemanek L, Bheemreddy B, Kaye KS, Sobel JD. Fluconazole-resistant Candida albicans vulvovaginitis. Obstet Gynecol. 2012;120(6):1407-1414. 4. Mintz, Martens MG. Prevalence of non-albicans Candida infections in women with recurrent vulvovagin*l symptomatology. Adv Infect Dis. 2013;3(4):238-242. 5. Data on file. Insight Pharmaceuticals LLC, a Prestige Consumer Healthcare company. Tarrytown, NY; 2015. 6. Samra-Latif OM. Vulvovaginitis. http://emedicine.medscape.com/article/2188931-overview. Published March 27, 2014. Accessed March 12, 2015. 7. Mølgaard-Nielsen D, Svanström H, Melbye M, Hviid A, Pasternak B. Association between use of oral fluconazole during pregnancy and risk of spontaneous abortion and stillbirth. JAMA. 2016;315(1):58-67. 8. US Food and Drug Administration. FDA Drug Safety Communication: FDA to review study examining use of oral fluconazole (Diflucan) in pregnancy. https://www.fda.gov/Drugs/DrugSafety/ucm497482.htm. Published April 26, 2016. Accessed January 22, 2018. 9. Goswami D, Goswami R, Banerjee U, et al. Pattern of Candida species isolated from patients with diabetes mellitus and vulvovagin*l candidiasis and their response to single dose oral fluconazole therapy. J Infect. 2006;52(2):111-117. 10. Nyirjesy P and Sobel JD. Genital mycotic infections in patients with diabetes. Postgrad Med. 2015;125(3):33-46. 11. May M and Schindler C. Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016;7(2):69-83. 12. Diflucan [prescribing information]. New York, NY: Roerig. 2013. 13. Sola D, Rossi L, Schianca GPC, et al. Sulfonylureas and their use in clinical practice. Arch Med Sci. 2015;11(4):840-848. 14. A 2017 survey of OB/GYNs (n=200) asked: Which of the following best describes your approach to prescribing fluconazole for yeast infection in pregnant patients? (Throughout pregnancy; Trimesters 2 and 3; Trimester 3; Do not prescribe during pregnancy). 15. A 2017 survey of OB/GYNs (n=200) asked: When treating a vagin*l yeast infection in women with diabetes, which do you recommend most often? (Butoconazole; Fluconazole; Miconazole; Terconazole). 16. ISSVD. (2019). Vulvovagin*l Candidiasis: Diagnosis and Treatment Tips (Version 1.3) [Mobile application software]. Retrieved from http://itunes.apple.com. 17. Postelnick M. Yeast infections in pregnancy: recommended treatments. http://www.medscape.com/viewarticle/866590. Published July 29, 2016. Accessed August 26, 2017. 18. Richter SS, et al. Antifungal susceptibilities of Candida species causing vulvovaginitis and epidemiology of recurrent cases. J Clin Microbiol. 2005;43(5):2155-2162. 19. Hylton Gravatt LA, Flurie RW, Lajthia E, Dixon DL. Clinical guidance for managing statin and antimicrobial drug-drug interactions. Curr Atheroscler Rep. 2017;19:46. 20. A 2017 survey of OB/GYNs (n=200) and women’s health NPs and PAs (n=200) asked: Compared to your past prescribing practices (e.g., 3-5 years ago), how often do you currently prescribe more than one pill of fluconazole (150 mg) for uncomplicated vagin*l yeast infection (i.e., mild-to-moderate and infrequent)? (More often, Less often, About the same, Do not prescribe). 21. A 2017 survey of OB/GYNs (n=200) and women’s health NPs and PAs (n=200) asked: In patients unresponsive to a single 150 mg dose of fluconazole, how often have you suspected microbial resistance? (Often, Occasionally, Rarely, Never). 22. Bérard A, Sheehy O, Zhao JP, et al. Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies. CMAJ. 2019;191:E179-E187. 23. IRI vagin*l Antifungal Category Latest 52 Week Pd Ending 09-06-20.