Vitamin D2 vs. D3: What’s the Difference? (2024)

You can get vitamin D3 from sun exposure and meat, such as fish oil and egg yolk. You can get vitamin D2 from plants.

Vitamin D is more than just one vitamin. It’s a family of nutrients that shares similarities in chemical structure.

In your diet, the most commonly found members are vitamin D2 and D3. While both types help you meet your vitamin D requirements, they differ in a few important ways.

Research even suggests that vitamin D2 is less effective than vitamin D3 at raising blood levels of vitamin D.

This article sums up the main differences between vitamin D2 and D3.

Vitamin D is a fat-soluble vitamin that promotes the absorption of calcium, regulates bone growth and plays a role in immune function.

Your skin produces vitamin D when it’s exposed to sunlight. However, if you spend most of your time indoors or live at a high latitude, you’ll need to get this vitamin from your diet.

Good dietary sources include fatty fish, fish oils, egg yolk, butter and liver.

However, it may be difficult to get adequate amounts of this vitamin from your diet alone, as rich natural sources are rare. For these reasons, it’s common for people to not get enough.

Luckily, many food manufacturers add it to their products, especially milk, margarine and breakfast cereals. Supplements are also popular.

To prevent deficiency symptoms, make sure to eat vitamin D-rich foods regularly, get some sunlight or take supplements.

Since vitamin D is fat-soluble, it is better to choose oil-based supplements or take them with food that contains some fat (1).

The vitamin comes in two main forms:

  • Vitamin D2 (ergocalciferol)
  • Vitamin D3 (cholecalciferol)

Their differences are discussed in detail below.

Summary Vitamin D is a
fat-soluble vitamin that exists in two main forms: vitamin D2 (ergocalciferol)
and vitamin D3 (cholecalciferol).

Vitamin D3 Comes from Animals, Vitamin D2 from Plants

The two forms of vitamin D differ depending on their food sources.

Vitamin D3 is only found in animal-sourced foods, whereas D2 mainly comes from plant sources and fortified foods.

Sources of Vitamin D3

  • Oily fish and fish oil
  • Liver
  • Egg yolk
  • Butter
  • Dietary supplements

Sources of Vitamin D2

  • Mushrooms (grown in UV light)
  • Fortified foods
  • Dietary supplements

Since vitamin D2 is cheaper to produce, it’s the most common form in fortified foods.

Summary Vitamin D3 is only
found in animals, while vitamin D2 comes from plant-sourced foods.

Vitamin D3 Is Formed in Your Skin

Your skin makes vitamin D3 when it’s exposed to sunlight.

Specifically, ultraviolet B (UVB) radiation from sunlight triggers the formation of vitamin D3 from the compound 7-dehydrocholesterol in skin (2).

A similar process takes place in plants and mushrooms, where UVB light leads to the formation of vitamin D2 from ergosterol, a compound found in plant oils (3).

If you regularly spend time outdoors, lightly clad and without sunscreen, you may be getting all the vitamin D you need.

In Indian people, an estimated half an hour of midday sun twice a week provides the adequate amount (4).

Just keep in mind that this duration of exposure does not apply in countries farther away from the equator. In these countries, you may need more time to achieve the same results.

Nevertheless, be careful not to spend too much time in the sun without sunscreen. This is especially important if you have light-colored skin. Sunburns are a major risk factor for skin cancer (5).

Unlike dietary vitamin D, you cannot overdose on vitamin D3 produced in your skin. If your body already has enough, your skin simply produces less.

That said, many people get very little sun. They either work indoors or live in a country that doesn’t get much sunlight during the winter. If this applies to you, make sure to regularly eat plenty of food rich in vitamin D.

Summary Your skin produces
vitamin D3 when you spend time in the sun. In contrast, vitamin D2 is produced
by plants and mushrooms exposed to sunlight.

Vitamin D3 Is More Effective at Improving Vitamin D Status

Vitamin D2 and D3 are not equal when it comes to raising your vitamin D status.

Both are effectively absorbed into the bloodstream. However, the liver metabolizes them differently.

The liver metabolizes vitamin D2 into 25-hydroxyvitamin D2 and vitamin D3 into 25-hydroxyvitamin D3. These two compounds are collectively known as calcifediol.

Calcifediol is the main circulating form of vitamin D, and its blood levels reflect your body’s stores of this nutrient.

For this reason, your health care provider can estimate your vitamin D status by measuring your levels of calcifediol (6).

However, vitamin D2 seems to yield less calcifediol than an equal amount of vitamin D3.

Most studies show that vitamin D3 is more effective than vitamin D2 at raising blood levels of calcifediol (7, 8).

For example, one study in 32 older women found that a single dose of vitamin D3 was nearly twice as effective as vitamin D2 at raising calcifediol levels (9).

If you are taking vitamin D supplements, consider choosing vitamin D3.

Summary Vitamin D3 appears to
be better than D2 at improving vitamin D status.

Vitamin D2 Supplements Might Be Lower Quality

Scientists have raised concerns that vitamin D2 supplements might be lower quality than D3 supplements.

In fact, studies suggest vitamin D2 is more sensitive to humidity and fluctuations in temperature. For this reason, vitamin D2 supplements may be more likely to degrade over time (10).

However, whether this is relevant to human health is unknown. Also, no studies have compared the stability of vitamin D2 and D3 dissolved in oil.

Until new research proves otherwise, you shouldn’t worry about the quality of your vitamin D2 supplements. Simply make sure to store your supplements in a closed container, at room temperature, in a dry place and out of direct sunlight.

Summary Vitamin D2 supplements
may be more likely to degrade during storage. However, it’s unknown whether the
same applies to oil-based vitamin D2. More studies are needed to examine the
relevance of this to human health.

How to Improve Your Vitamin D Status

Fortunately, there are many ways you can improve your vitamin D status.

Below are a few ideas:

  • Select
    mushrooms that have been exposed to ultraviolet light (11)
  • Take
    fish oil supplements such as cod liver oil
  • Eat
    fatty fish twice a week (12)
  • Choose
    milk or orange juice that’s been fortified with vitamin D
  • Eat
    some eggs and butter (13)
  • Spend
    at least half an hour in the sun daily, if possible

If you take vitamin D supplements, make sure not to exceed the safe upper intake level, which is 4,000 IU (100 micrograms) per day for adults (14).

According to the US Institute of Medicine, the recommended daily allowance is 400–800 IU (10–20 micrograms), but common supplemental doses range from 1,000–2,000 IU (25–50 micrograms) per day.

For detailed information on the optimal dosage of vitamin D, read this article.

Summary You can increase your
vitamin D levels by regularly eating foods rich in vitamin D and spending time
in the sun.

The Bottom Line

Vitamin D is not a single compound but a family of related nutrients. The most common dietary forms are vitamins D2 and D3.

The D3 form is found in fatty animal-sourced foods, such as fish oil and egg yolk. Your skin also produces it in response to sunlight or ultraviolet light. In contrast, vitamin D2 comes from plants.

Interestingly, vitamin D3 appears to be more effective at increasing levels of vitamin D in the blood. Although, scientists debate the relevance of this to human health.

To maintain adequate vitamin D levels, make sure to regularly eat plenty of foods rich in vitamin D or spend some time in the sun. If you take supplements, vitamin D3 is probably your best choice.

Vitamin D2 vs. D3: What’s the Difference? (2024)

FAQs

Vitamin D2 vs. D3: What’s the Difference? ›

Both play the same role in the body, but vitamins D2 and D3 have slightly different molecular structures. The main difference is that vitamin D2 comes from plants, whereas D3 comes from animals, including people. Scientists are not sure yet if one is better than the other for human health.

Is there a big difference between vitamin D2 and D3? ›

While both vitamin D3 and vitamin D2 can raise blood levels of vitamin D, vitamin D3 (cholecalciferol) is generally considered more effective due to its superior absorption and close resemblance to the form produced naturally by our bodies.

Why would doctors prescribe D2 instead of D3? ›

On the other hand, vitamin D2 is sourced from plants, and vitamin D3 is derived from animals. If you prefer a plant-based product, vitamin D2 is a better choice for you. Additionally, your doctor may recommend vitamin D2 as the best option for you if you have chronic kidney disease.

Why would a doctor prescribe 50,000 units of vitamin D? ›

If the amount in your blood is below 20 ng/mL, your levels are inadequate; if it's below 12 ng/mL, that means you're deficient in the nutrient. If that's the case, your doctor may prescribe a megadose of 50,000 IUs to take once a week for six to 12 weeks to raise the level of vitamin D circulating in your body.

What does D2 do for your body? ›

Vitamin D (ergocalciferol-D2, cholecalciferol-D3, alfacalcidol) is a fat-soluble vitamin that helps your body absorb calcium and phosphorus. Having the right amount of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.

Who should not take vitamin D3? ›

Caution is advised if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Is it okay to take vitamin D2 every day? ›

Taken in appropriate doses, vitamin D is generally considered safe. However, taking too much vitamin D in the form of supplements can be harmful. Children age 9 years and older, adults, and pregnant and breastfeeding women who take more than 4,000 IU a day of vitamin D might experience: Nausea and vomiting.

Can I take 5000 IU of vitamin D3 every day? ›

Some people may need a higher dose, however, including those with a bone health disorder and those with a condition that interferes with the absorption of vitamin D or calcium, says Dr. Manson. Unless your doctor recommends it, avoid taking more than 4,000 IU per day, which is considered the safe upper limit.

How much D3 should you take a day? ›

In people with vitamin D levels less than 20 ng/mL, they often start with 50,000 IU of vitamin D3, once a week for 6 to 8 weeks. After that, a dose of 800 IU to 2,000 IU per day can help maintain vitamin D levels above 30 ng/mL.

Is D2 or D3 better for osteoporosis? ›

There are two types of vitamin D supplements. They are vitamin D2 and vitamin D3. Previous research suggested that vitamin D3 was a better choice than vitamin D2. However, more recent studies show that vitamin D3 and vitamin D2 are fairly equal for bone health.

Is it safe to take 50,000 IU of vitamin D3 once a week? ›

Vitamin D supplement safety

Healthcare professionals may recommend people who are very low in vitamin D take very high weekly doses of 50,000 IU for 8 weeks, followed by a maintenance dose of 2,000 IU per day after their levels reach 30 ng/mL ( 15 ).

Is it better to take vitamin D3 every day or once a week? ›

“Most patients who require vitamin D supplements should take a small daily dose,” Nate Wood, MD, Instructor of General Medicine at Yale Medicine, told Health. “For patients who are severely deficient in vitamin D, a larger weekly dose may be prescribed for the short-term.”

What's the worst that can happen with low vitamin D? ›

When vitamin D levels are low and the body isn't able to properly absorb calcium and phosphorus, there is an increased risk of bone pain, bone fractures, muscle pain, and muscle weakness. In older adults, severe vitamin D deficiency (levels less than 10 ng/mL) may also contribute to an increased risk of falls.

Why take D2 instead of D3? ›

Both versions are similar molecules. The main difference is that D2 comes from plants, and D3 comes from animals. Both D2 and D3 will raise your vitamin D levels. But research suggests that D3 is slightly more effective.

Why would a doctor prescribe vitamin D2? ›

Vitamin D2 (ergocalciferol) is a form of vitamin D that's available both over the counter or with a prescription, depending on the dose. It's used to treat vitamin D deficiency (low vitamin D levels), including in various medical conditions, such as hypoparathyroidism (low parathyroid hormone) and rickets.

What are the symptoms of too much vitamin D2? ›

Symptoms and Causes
  • Decrease in appetite.
  • Nausea and vomiting.
  • Constipation.
  • Dehydration.
  • Increased thirst (polydipsia).
  • Frequent urination.
  • Confusion, lethargy and fatigue.
  • Muscle weakness and difficulty walking.
Feb 21, 2023

What form of vitamin D is best? ›

Two forms of vitamin D are available in supplements: vitamin D3 and vitamin D2. Both can help correct vitamin D deficiency, but most doctors recommend D3 because it is slightly more active and therefore slightly more effective. Vitamin D3 is naturally produced by animals, including humans. Vitamin D2 is the plant form.

Is 50,000 vitamin D2 safe? ›

Typical dosing for Vitamin D2 (ergocalciferol)

Hypoparathyroidism: The typical dose ranges between 50,000 and 200,000 units (or international units, IU) by mouth every day, along with calcium supplementation.

Can you take vitamin D2 and vitamin D3 together? ›

Ultimately both vitamin D2 and D3 get converted through enzymatic reactions in the liver and kidneys to the active form of vitamin D and can be taken together [1]. So, in simple terms, the answer is YES! You can take vitamin D and D3 together.

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